RAGNO Rino

Qualifica (it.): 
Professore II fascia
SSD: 
CHIM/08
Indirizzo e-mail: 
Fax: 
+39 06 4991 3627
Ricevimento studenti: 

Tutti i giorni dalle 08:00 alle 09:00 previo appuntamento per e-mail.

Rino Ragno è Professore Associato della Facoltà di Farmacia e Medicina di Sapienza Università di Roma, dove si è laureato con lode nel 1989 in Chimica e Tecnologia Farmaceutiche svolgendo una tesi sperimentale in chimica farmaceutica di sintesi sotto la guida del prof. Silvio Massa. Dal 1990 al 2000 ha lavorato come assistente nei laboratori di ricerca chimico-farmaceutica del prof. Marino Artico eseguendo progetti inerenti la sintesi di molecole ad attività antifungina, antitubercolare ed antivirale. Nel 1992 il prof. Ragno ha anche acquisito la laurea in Farmacia diplomandosi con lode. Dal 1990 il Prof. Rino Ragno ha iniziato ad interessarsi di progettazione chimico farmaceutica tramite l’ausilio del calcolatore. Ha così frequentato numerosi corsi di perfezionamento sulla chimica computazionale con particolare riguardo all’applicazione nella chimica farmaceutica. Nel 1996 e nel 1998 ha trascorso due anni a St Louis in Missouri nei laboratori del prof Garland R. Marshall dove ha completato la sua formazione nel campo della chimica farmaceutica computazionale.

Dal 2000 ha iniziato un laboratorio di progettazione chimico-farmaceutica chiamato RCMD (Rome Center for Molecular Design, http://www.rcmd.it)

Nel periodo più recente il Prof. Rino Ragno ha focalizzato la sua ricerca in due principali campi: (1) progettazione e sintesi di nuovi composti antivirali ad attività anti-HIV (anti-RT, anti-IN e anti-PR). (2) progettazione e sintesi di nuovi composti capaci di interagire con proteine enzimatiche e non coinvolte nei processi trascrizionali di attivazione e nel rimodellamento della cromatina.

Il Prof. Rino Ragno si è reso partecipe di oltre 90 pubblicazioni su riviste internazionali ad alto valore di fattore di impatto, un brevetto nazionale, due brevetti internazionali e oltre 100 comunicazioni a convegni nazionali ed internazionali.

Infine come membro della Facoltà di Farmacia e Medicina dal 2000 a tutt’oggi il Prof. Rino Ragno è incaricato dell’insegnamento di corsi nel settore scientifico disciplinare CHIM08 sia in lauree di I° livello (Biotecnologie, Scienze Farmaceutiche Applicate) che specialistiche (Biotecnologie Farmaceutiche e Chimica e Tecnologia Farmaceutiche).

Nel 2016 il Prof. Rino Ragno ha iniziato una StartUp universitaria dal nome Alchemical Dynamics con l'obiettivo di applicare e commercializzare l'esperienza maturata in oltre 25 anni di ricerca.

 

Aree di afferenza: 
- Area Farmaceutica
- Corso di Laurea in Biotecnologie
- Corso di Laurea in Scienze Farmaceutiche Applicate
- Corso di Laurea Specialistica in Biotecnologie Farmaceutiche
Tesi disponibili: 

Ogni anno sono disponibili 2-3 posti di tesi sperimentale nell'ambito della Chimica Farmaceutica Computazionale e Progettazione Farmaci. Durante la tesi sperimentale gli studenti impareranno ad utilizzare strumenti di chimica computazionale (3-D QSAR, Docking molecolare, ecc) per la razionalizzazione delle relazioni struttura-attività e per la progettazione ad-hoc di molecole bioattive.

Curriculum vitae (it): 
Curriculum vitae (en): 
Pubblicazioni: 
  • S. MASSA, M. ARTICO, A. MAI, R. RAGNO, F. CORELLI, A. PANI, M.E. MARONGIU, E. TRAMONTANO, P. LA COLLA. Synthesis of New Disoxaril Analogues with Potent and Selective Anti-Human Rhinovirus 14 Activity. Bioorganic and Medicinal Chemistry Letters, 1, 575-578 (1991).
  • S. MASSA, R. RAGNO, G.C. PORRETTA, A. MAI, A. RETICO, M. ARTICO, N. SIMONETTI. ANTIFUNGAL AGENTS, II: Synthesis and Antifungal Activities of Aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methane Derivatives with Unsaturated Chains. Archiv Pharm. (Weinheim), 326, 539-546 (1993). 
  • S. MASSA, A. MAI, R. RAGNO, G.C. PORRETTA, A. RETICO, G. SIMONETTI, M. ARTICO. ANTIFUNGAL AGENTS. 7. Dichlorophenylpyrrylimidazolylmethane Derivatives: Synthesis and Antifungal Activities. Il Farmaco, 49, 51-55 (1994)
  • S. MASSA, F. CORELLI, M. ARTICO, A. MAI, R. RAGNO, A. DE MONTIS, A.G. LOI, S. CORRIAS, M.E. MARONGIU, P. LA COLLA. [[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(Pyrrylcarbonyl)alkyl]oxy]phenyl] oxazoline Derivatives with Potent and Selective Antihuman Rhinovirus Activity. Journal of Medicinal Chemistry, 38, 803-809 (1995).
  • R. RAGNO, M. BOTTA, F. CORELLI, A. MAI, S. MASSA, G.C. PORRETTA, M. ARTICO. Comparative Molecular Field Analysis of New Human Rhinovirus-14 Inhibitors. QSAR AND MOLECULAR MODELLING: CONCEPTS, COMPUTATIONAL TOOLS AND BIOLOGICAL APPLICATIONS , pp. 488-492 (1995); F. Sanz, J. Giraldo and F. Manaut (Eds.); Prous Science Publishers.
  • MAI, M. ARTICO, S. MASSA, R. RAGNO, A. DE MONTIS, S. CORRIAS, M.G. SPIGA, P. LA COLLA. Methyl-2-thienylketopolymethylenoxyphenyl derivatives of alkyl-substituted 4,5-dihydro-2-oxazoles with anti-human picornavirus activity. Antivir. Chem. Chemother., 7, 213-220 (1996).
  • M. ARTICO, M. BOTTA, F. CORELLI, A. MAI, S. MASSA, R. RAGNO. Investigation on QSAR and Binding Mode of a New Class of Human Rhinovirus-14 Inhibitors by CoMFA and Docking Experiments. Bioorganic and Medicinal Chemistry, 4, 1715-1724 (1996).
  • A.TAFI, Y.ANASTASSOPOULOU, T.THEOPHANIDES, M.BOTTA, F.CORELLI, M.ARTICO, R.COSTI, R.DI SANTO, S.MASSA, R.RAGNO Molecular Modeling of Azole Antifungal Agents Active.Againts Candida Albicans.I: a CoMFA Study. Journal of Medicinal Chemistry , 39,1227-1235 (1996).
  • M.ARTICO, R.RAGNO, G.C.PORRETTA, S.MASSA, C.MUSIU, M.G.SPIGA, S.CORRIAS, P. LA COLLA. Iso-Miconazole and Related Derivatives: Synthesis and Antifungal Activities. Med Chem Research, 6,137-147 (1996)
  • ETTORRE, M. ARTICO, A. MAI, R. RAGNO, G. C. PORRETTA, S. MASSA. Crystal structure of 2-[5-(4-carbethoxyphenoxy)pentanoyl]-5-chlorothiophene. Z. Kristallogr. NCS, 213, 129-130 (1998).
  • Garland R. Marshall, Rino Ragno et aL. Bound conformations for ligands for G-protein coupled receptors. Letters in Peptide Science, 6: 283-288, (1999)
  • Rino Ragno, Garland R. Marshall et al.. Antimycobacterial Pyrroles: Synthesis, anti-Mycobacterium tuberculosis Activity and QSAR . Bioorganic and Medicinal Chemistry, 8, 1-10, (2000)
  • Garland R. Marshall, Richard D. Head and Rino Ragno. Affinity Prediction: The Sine Qua Non. Thermodinamics in Biology, Enrico di Cera, Editor, Oxford University Press. 87-111. 2000
  • Mai, A., Sbardella, G., Artico, M., Ragno, R., Massa, S., Novellino, E., Greco, G., Lavecchia, A., Musiu, C., La Colla, M., Murgioni, C., La Colla, P., and Loddo, R. . Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6- difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non- nucleoside inhibitors of HIV-1 reverse transcriptase.  Journal of Medicinal Chemistry 44, 2544-54. 2001
  • Massa, S., Mai, A., Sbardella, G., Esposito, M., Ragno, R., Loidl, P., and Brosch, G.  3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. . Journal of Medicinal Chemistry 44, 2069-72. 2001
  • Quaglia, M., Mai, A., Sbardella, G., Artico, M., Ragno, R., Massa, S., del Piano, D., Setzu, G., Doratiotto, S., and Cotichini, V. . Chiral resolution and molecular modeling investigation of rac-2- cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5- methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class.  Chirality 13, 75-80. 2001
  • Romano Silvestri, Marino Artico,* Gabriella De Martino, Rino Ragno, Silvio Massa, Roberta Loddo, Chiara Murgioni, Anna Giulia Loi, Paolo La Colla,* and Alessandra Pani.  Synthesis, Biological Evaluation, and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase, . J. Med. Chem., 45, 1567-1576, 2002.
  • Antonello Mai, Silvio Massa, Rino Ragno, Monica Esposito, Gianluca Sbardella, Giuseppina Nocca, Roberto Scatena, Florian Jesacher, Peter Loidl, and Gerald Brosch.  Binding Mode Analysis of 3-(4-Benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: A New Synthetic Histone Deacetylase Inhibitor Inducing Histone Hyperacetylation, Growth Inhibition, and Terminal Cell Differentiation. J. Med. Chem. 2002, 45, 1778-1784
  • Roberto Di Santo, Roberta Costi,  Marino Artico, *  Silvio Massa, Rino Ragno, Garland R.  Marshall* and  Paolo La Colla. Design, Synthesis and QSAR Studies on N-Aryl Heteroarylisopropanolamines, a New Class of Non-Peptidic HIV-1 Protease Inhibitors. Bioorganic and Medicinal Chemistry, 10, 2002,  2511-2526.  
  • Roberto Di Santo, Roberta Costi, Marino Artico,* Silvio  Massa, RINO RAGNO, Massimiliano La Colla, Roberta Loddo, Paolo La Colla,* and Alessandra Pani. Arylthiopyridylmethylisopropylpyrrole carbinols, novel NNRTIs endowed with potent anti-HIV-1 activity.  Medicinal Chemistry Research, 11, 2002, 153-167
  • Romano Silvestri, Gabriella De Martino, Marino Artico, Giuseppe La Regina, Rino Ragno, Roberta Loddo, Paolo La Colla, Maria Elena Marongiu, Massimiliano La Colla, and Alessandra Pani. Anti-HIV-1 NNRT Agents: Acylamino Pyrryl Aryl Sulfones (APASs) as Truncated Analogues of Tricyclic PBTDs. Medicinal Chemistry Research, 11, 2002, 195-218.
  • Mai, A, S Massa, R Ragno, I Cerbara, F Jesacher, P Loidl, G Brosch, . 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures. . J Med Chem, 2003, 46, 512-24.
  • Mai, A, M Artico, M Esposito, R Ragno, G Sbardella, S Massa, Synthesis and biological evaluation of enantiomerically pure pyrrolyl- oxazolidinones as a new class of potent and selective monoamine oxidase type A inhibitors.  Il Farmaco, 2003, 58, 231-41
  • Roberta Costi, Roberto Di Santo, Marino Artico, Alessandra Roux, Rino Ragno, Silvio Massa, Enzo Tramontano, Massimiliano La Colla, Roberta Loddo, Maria Elena Marongiu, Alessandra Pani and Paolo La Colla.  2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays. Bioorganic and Medicinal Chemistry, 2004, 12, 199-215
  • Rino Ragno, Antonello Mai, Gianluca Sbardella, Marino Artico, Silvio Massa, Chiara Musiu, Massimo Mura, Flavia Marturana, Alessandra Cadeddu, and Paolo La Colla.  Computer-Aided Design, Synthesis, and Anti-HIV-1 Activity in Vitro of 2-Alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as Novel Potent Non-Nucleoside Reverse Transcriptase Inhibitors, Also Active Against the Y181C Variant.  J Med Chem, 2004, 47, 928-934
  • Mai, A.; Massa, S.; Cerbara, I.; Valente, S.; Ragno, R.; Bottoni, P.; Scatena, R.; Loidl, P.; Brosch, G.  3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity. J Med Chem, 2004, 47, 1098-1109
  • Rino Ragno, Antonello Mai, Silvio Massa, Ilaria Cerbara, Sergio Valente, Patrizia Bottoni, Roberto Scatena, Florian Jesacher, Peter Loidl, and Gerald Brosch. . 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 3. Discovery of Novel Lead Compounds Through Structure-Based Drug Design and Docking Studies. . J Med Chem, 2004, 47, 1351-1359.
  • Roberta Costi, Roberto Di Santo, Marino Artico, Alessandra Roux, Rino Ragno, Silvio Massa, Enzo Tramontano, Massimiliano La Colla, Roberta Loddo, M. Elena Marongiu, Alessandra Pani and Paolo La Colla . 6-Aryl-2,4-dioxo-5-hexenoic Acids, Novel Integrase Inhibitors Active Against HIV-1 Multiplication in Cell-Based Assays.  Bioorg. Med. Chem. Letters, 2004, 14, 1745-1749
  • Antonello Mai, Marino Artico, Rino Ragno, Gianluca Sbardella, Silvio Massa, Chiara Musiu, Massimo Mura, Flavia Marturana, Alessandra Cadeddu, Giovanni Maga and Paolo La Colla. 5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase. inhibitors belonging to the DABO family.  Bioorg. Med. Chem., 2005, 13, 2065–207
  • Rino Ragno, Simona Frasca, Fabrizio Manetti, Antonella Brizzi, and Silvio Massa.  HIV-Reverse Transcriptase Inhibition: Inclusion of Ligand-Induced Fit by Cross-Docking Studies. J. Med .Chem. 2005, 48, 200-212
  • Rino Ragno, Marino Artico, Gabriella De Martino, Giuseppe La Regina, Antonio Coluccia, Alessandra Di Pasquali, and Romano Silvestri.  Docking and 3-D QSAR Studies on Indolyl Aryl Sulfones (IASs). Binding Mode Exploration at the HIV-1 Reverse Transcriptase Non-Nucleoside Binding Site and Design of Highly Active N-(2-Hydroxyethyl)carboxyamide and N-(2-Hydroxyethyl)carboxy hydrazide Derivatives. J. Med .Chem. 2005, 48, 213-224
  • Antonello Mai, Silvio Massa, Dante Rotili, Ilaria Cerbara, Sergio Valente, Riccardo Pezzi, Silvia Simeoni, Rino Ragno.  Histone Deacetylation In Epigenetics: An Attractive Target For Anticancer Therapy.  Med. Res. Rev., 2005, 261-309
  • Agamennone Mariangela; Campestre Cristina; Preziuso Serena; Consalvi Valerio; Crucianelli Marcello; Mazza Fernando; Politi Vincenzo; Ragno Rino; Tortorella Paolo; Gallina Carlo. Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2. European Journal of Medicinal Chemistry, 2005, 40, 271-279
  • Gabriella De Martino, Giuseppe La Regina, Rino Ragno, Antonio Coluccia, Alberto Bergamini, Chiara Ciaprini, Anna Sinistro, Giovanni Maga, Emmanuele Crespan, Marino Artico, and Romano Silvestri.  Novel DAMNIs as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. A Structure Activity Relationships Investigation. J. Med .Chem., 2005, 48,4378-4388.
  • Di Santo, R.; Costi, R.; Artico, M.; Ragno, R.; Greco, G.; Novellino, E.; Marchand, C.; Pommier, Y.  . Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity.  Farmaco, 2005, 60, 409-417. 
  • Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA.  Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.  J. Med .Chem., 2005, 48, 7789-95.
  • Cancio R, Silvestri R, Ragno R, Artico M, De Martino G, La Regina G, Crespan E, Zanoli S, Hubscher U, Spadari S, Maga G. . High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.  Antimicrob Agents Chemother, 2005, 49, 4546-54
  • Roberto Di Santo, Roberta Costi, Marino Artico, Rino Ragno, Antonio Lavecchia, Ettore Novellino, Enrico Gavuzzo, Francesco La Torre, Roberto Cirilli, Reynel Cancio, Giovanni Maga. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.  ChemMedChem, 2006, 1, 82-95
  • AntonelLo Mai, Silvio Massa, Sergio Valente, Silvia Simeoni, Rino Ragno, Patrizia Bottoni, Roberto Scatena, Gerald Brosch.  Aroyl-Pyrrolyl Hydroxyamides: Influence of Pyrrole C4-Phenylacetyl Substitution on Histone Deacetylase Inhibition . ChemMedChem, 2006, 1, 1, 225-237
  • Fabrizio Manetti, Cristina Tintori, Mercedes Armand-Ugón, Imma Clotet-Codina, Silvio, Massa, Rino Ragno, José A. Esté, and Maurizio Botta. A Combination of Molecular Dynamics and Docking Calculations to Explore the Binding Mode of ADS-J1, a Polyanionic Compound Endowed with Anti-HIV-1 Activity. J. Chem. Inf. Model. Accepted for publication, 2006, 46, 1344-1351
  • Gabriella De Martino, Giuseppe La Regina, Rino Ragno, Antonio Coluccia, Alberto Bergamini, Chiara Ciaprini, Anna Sinistro, Giovanni Maga, Emmanuele Crespan, Marino Artico and Romano Silvestri. Indolyl Aryl Sulfones (IASs) as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Synthesis, Biological Evaluation and Binding Mode Studies of New Derivatives at Indole-2-carboxamide. Antiviral Chemistry & Chemotherapy, 2006, 17, 59-77
  • Rino Ragno, Silvia Simeoni, Sergio Valente, Silvio Massa, and Antonello Mai.  3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds.  J. Chem. Inf. Model., 2006, 46, 1420-30
  • Ragno R, Coluccia A, La Regina G, De Martino G, Piscitelli F, Lavecchia A, Novellino E, Bergamini A, Ciaprini C, Sinistro A, Maga G, Crespan E, Artico M, Silvestri R. . Design, Molecular Modeling, Synthesis and anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-Carboxamide.  J. Med .Chem., 2006, 49(11),3172-84.
  • Antonello Mai, Silvio Massa, Dante Rotili, Silvia Simeoni, Rino Ragno, Giorgia Botta, Angela Nebbioso, Lucia Altucci, and Gerald Brosch.  Synthesis, and Biological Properties of Novel, Uracil-Containing Histone Deacetylase Inhibitors. J. Med .Chem., 2006; 49(20); 6046-6056.
  • Rino Ragno, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri. Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3-D QSAR studies. Expert Opinion in Drug Discovery, 2007; 2, 87-114
  • RINO RAGNO, SILVIA SIMEONI, SABRINA CASTELLANO, CATERINA VICIDOMINI, ANTONELLO MAI, ANNA TRAMONTANO, CLAUDIA BONACCINI, PATRICK TROJER,D INGO BAUER, GERALD BROSCH, AND GIANLUCA SBARDELLA.  Small Molecule Inhibitors of Histone Arginine Methyltransferases: Homology Modeling, Molecular Docking, Binding Mode Analysis and Biological Evaluations J. Med .Chem 2007; 50(6); 1241 - 1253
  • Antonello Mai, Sergio Valente, Donghang Cheng, Andrea Perrone, Rino Ragno, Silvia Simeoni, Gianluca Sbardella, Gerald Brosch, and Mark T. Bedford.  Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors . ChemMedChem, 2007, 2(7), 987-991
  • Mai Antonello; Artico Marino; Rotili Dante; Tarantino Domenico; Clotet-Codina Imma; Armand-Ugon Mercedes Ragno, Rino; Simeoni Silvia; Sbardella Gianluca; Nawrozkij Maxim B.; Samuele Alberta; Maga Giovanni; Este Jose A.  Synthesis and Biological Properties of Novel 2-Aminopyrimidin-4(3H)-ones Highly Potent against HIV-1 Mutant Strains.  Journal of Medicinal Chemistry, 2007, 50(22), 5412-5424
  •  Rino Ragno, Silvia Simeoni, Dante Rotili, Antonella Caroli, Giorgia Botta, Gerald Brosch, Silvio Massa, and Antonello Mai. Class II-Selective Histone Deacetylase Inhibitors. Part 2. Alignment-Independent GRIND 3-D QSAR, Homology and Docking Studies.  European Journal of Medicinal Chemistry, 2008, 43(3), 621-632

 

  • Nawrozkij, Maxim B.; Rotili, Dante; Tarantino, Domenico; Botta, Giorgia; Eremiychuk, Alexandre S.; Musmuca, Ira; Ragno, Rino; Samuele, Alberta; Zanoli, Samantha; Armand-Ugon, Mercedes; Clotet-Codina, Imma; Novakov, Ivan A.; Orlinson, Boris S.; Maga, Giovanni; Este, Jose A.; Artico, Marino; Mai, Antonello.  5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a Series of Anti-HIV-1 Agents of the Dihydro-alkoxy-benzyl-oxopyrimidine Family with Peculiar Structure-Activity Relationship Profile . Journal of Medicinal Chemistry, 2008; 51(15); 4641-4652
  • Sabrina Castellano, Giorgio Stefancich, Rino Ragno, Katarzyna Schewe, Marisabella Santoriello, Antonia Caroli, Rolf W. Hartmann, Gianluca Sbardella. CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors.  Bioorganic & Medicinal Chemistry, 2008., 16 (18), 8349-58
  • Pietro Laneve, Ubaldo Gioia, Rino Ragno, Fabio Altieri, Carmen Di Franco, Tiziana Santini, Massimo Arceci, Irene Bozzoni, and Elisa Caffarelli.  The tumor marker human placental protein 11 is an endoribonuclease.  J. Biol. Chem. 2008, 283(50): 34712–34719
  • R. Ragno, S. Sivric, G. Sartorelli, A. Serilli, E. Vavala, L. Angiolella.  In vitro activity of essential oil of Myrtus communis L. against Candida albicans.  International Journal of Essential Oil Therapeutics (2008) 2, 156-157
  • Antonello Mai, Sergio Valente, Angela Nebbioso, Silvia Simeoni, Rino Ragno, Silvio Massa, Gerald Brosch, Floriana De Bellis, Fabio Manzo and Lucia Altucci.  New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations. The International Journal of Biochemistry & Cell Biology, 2009, 41 (1), 235-247
  • Ira Musmuca, Silvia Simeoni, Antonia Caroli, and Rino Ragno. Small-Molecule Interferon Inducers. Toward the Comprehension of the Molecular Determinants through Ligand-Based Approaches.  J. Chem. Inf. Model., 2009, 49, 1777-86, DOI: 10.1021/ci900065a
  • Elisabetta Vavala, Rino Ragno, Silvia Sivric, Gianni Sartorelli, Antonello Filippi, Anna Teresa Palamara, Letizia Angiolella. Antimycotic activity of Achillea ageratum L essential oil.  International Journal of Essential Oil Therapeutics (2009) 3, 1-5, ISSN:1961-4209
  • Sabrina Castellano, Ciro Milite, Rino Ragno, Silvia Simeoni, Antonello Mai, Ettore Novellino, Ingo Bauer, Gerald Brosch, Astrid Spannhoff, Donghang Cheng, Mark T. Bedford and Gianluca Sbardella. Design, Synthesis and Biological Evaluation of Carboxy- Analogues of Arginine Methyltransfe-rase Inhibitor 1 (AMI-1).  ChemMedChem, 2010, 5, 398-414
  • Ira Musmuca, Antonia Caroli, Antonello Mai, Neerja Kaushik-Basu, Payal Arora and Rino Ragno*. Combining 3-D QSAR with Ligand Based and Structure Based Alignment Procedures for in Silico Screening of New Hepatitis C Virus NS5B Polymerase Inhibitors. J. Chem. Inf. Model.,  2010, 50(4),  662-676
  • Letizia Angiolella, Elisabetta Vavala, Silvia Sivric, D’Auria Felicia Diodata, Rino Ragno.  In vitro activity of essential oil of Mentha suaveolens. against Cryptococcus neoformans , and dermatophytes. International Journal of Essential Oil Therapeutics (2010), 4(1-2),  35-36. 
  • Sergio Valente, Maria Tardugno, Mariarosaria Conte, Roberto Cirilli, Andrea Perrone, Rino Ragno, Silvia Simeoni, Silvio Massa, Angela Nebbioso, Marco Miceli,[b] Gianluigi Franci,Gerald Brosch, Lucia Altucci, and Antonello Mai. Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity. ChemMedChem, 2011, 6(4),  698-712
  • Pepi, Federico; Mazzei, Franco; Frasconi, Marco; Favero, Gabriele; Giacomello, Pierluigi; Tata, Alessandra; garzoli, stefania; Di Fusco, Massimo; D'Annibale, Andrea; Ragno, Rino; Patsilinakos, Alexandros; Cannistraro, Salvatore; Baldacchini, Chiara.  Chemically modified multi-walled carbon nanotubes electrodes with ferrocene derivatives through reactive landing.  The Journal of Physical Chemistry (2011), 115(11),  4863-4871
  • Nocca, G.; Ragno, R.; Carbone, V.; Martorana, G. E.; Rossetti, D. V.; Gambarini, G.; Giardina, B.; Lupi, A. Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis. Dental Materials (2011), 27:e87-98
  • Pietrella D., Angiolella L., Vavala E., Rachini A., Mondello F., Ragno R., Bistoni F., Vecchiarelli A. Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection.  BMC complementary and alternative medicine  (2011),  11, 18
  • Ragno R, Gioia U, Laneve P, Bozzoni I, Mai A, Caffarelli E.  Identification of Small-Molecule Inhibitors of the XendoU Endoribonucleases Family.  ChemMedChem. 2011 Oct 4;6(10):1797-805. doi: 10.1002/cmdc.201100281. Epub 2011 Jul 29.
  • Daniel Brian Nichols, Guy Fournet, Gurukumar K.R., Amartya Basu, Jin-Ching Lee, Naoya Sakamoto, Frank Kozielski, Ira Musmuca, Benoît Joseph,* Rino Ragno,* Neerja Kaushik-Basu*. Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-LCysteine Derivatives. Eur. J. Med Chem.  2012. 49C, 191-9
  • Dante Rotili, Alberta Samuele, Domenico Tarantino, Rino Ragno, Ira Musmuca, Flavio Ballante, Giorgia Botta, Ludovica Morera, Marco Pierini, Roberto Cirilli, Maxim B. Nawrozkij, Emmanuel Gonzalez, Bonaventura Clotet, Marino Artico, José A. Esté, Giovanni Maga, and Antonello Mai. 2-(Alkyl/Aryl)Amino-6-Benzylpyrimidin-4(3H)-ones as Inhibitors of Wild Type and Mutant HIV-1: Enantioselectivity Studies. Journal of Medicinal Chemistry, 2012., 55 (7), 3558-3562
  • Flavio Ballante, Ira Musmuca, Garland R. Marshall1 and Rino Ragno*.  Comprehensive Models of Wild-Type and Mutant HIV-1 Reverse Transciptases.  Journal of Computer-Aided Molecular Design. 2012. 26:907-19.
  • Flavio Ballante and Rino Ragno*. 3-D QSAutogrid/R: an alternative procedure to build 3-D QSAR models. Methodologies and applications. J. Chem. Inf. Model., 2012, 52:1674-85
  • Laura Silvestri, Flavio Ballante, Antonello Mai, Garland R. Marshall and Rino Ragno*. Histone Deacetylase Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction. J. Chem. Inf. Model., 2012; 52:2215-35
  • Simona Piccolelli, Andrina Ricci, Federico Pepi, Alexandros Patsilinakos, Rino Ragno, Stefania Garzoli and Pierluigi Giacomello. Gas-phase basicity of 2-furaldehyde. J. Mass Spectrom. 2012, 47, 1488–1494
  • Giorgio Ortar, Enrico Morera, Luciano De Petrocellis, Alessia Ligresti, Aniello Schiano Moriello, Ludovica Morera, Marianna Nalli, Rino Ragno, Adele Pirolli, Vincenzo Di Marzo. Biaryl tetrazolyl ureas inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring. European Journal of Medicinal Chemistry 63 (2013) 118-132
  • E. Perspicace, V. Jouan-Hureaux, R. Ragno*, F. Ballante, S. Sartini, C. La Motta, F. Da Settimo, B. Chen, G. Kirsch, S. Schneider, B. Faivre, S. Hesse, Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), European Journal of Medicinal Chemistry. (2013), doi: 10.1016/j.ejmech.2013.03.022,  63, 765–78
  • Laura Friggeri, Flavio Ballante, Rino Ragno*, Ira Musmuca, Daniela De Vita, Fabrizio Manetti, Mariangela Biava, Luigi Scipione, Roberto Di Santo, Roberta Costi, Marta Feroci and Silvano Tortorella. Pharmacophore Assessment Through 3-D QSAR:evaluation of the predictive ability on new derivatives by the application on a serie of antituberculara gents. DOI: 10.1021/ci400132q. J. Chem. Inf. Model., (2013), 53 (6), pp 1463–1474
  • Livia Civitelli; Simona Panella; Maria Elena Marcocci; Alberto De Petris; Stefania Garzoli; Federico Pepi; Elisabetta Vavala; Rino Ragno; Lucia Nencioni; Anna Teresa Palamara; Letizia Angiolella. In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil  and its main component piperitenone oxide. Phytomedicine (2014). In Press, doi:10.1016/j.phymed.2014.01.013
  •  Maria Chatzopoulou, Alexandros Patsilinakos, Theodosia Vallianatou, Marta Soltesova Prnova, Simon Žakelj, Rino Ragno, Milan Stefek, Albin Kristl, Anna Tsantili-Kakoulidou, and Vassilis J. Demopoulos . Decreasing acidity in a series of aldose reductase inhibitors: 2-fluoro-4-(1H-pyrrol- 1-yl)phenol as a scaffold for improved membrane permeation Biorganic Medicinal Chemistry (2014), Volume 22, Issue 7, 1 April 2014, Pages 2194–2207

 

  • Flavio Ballante, Antonia Caroli, Richard B. Wickersham III and Rino Ragno. Hsp90 Inhibitors (I). Definition of 3-D QSAutogrid/R Models as a Tool for Virtual Screening, J. Chem. Inf. Model., (2014), 54 (3), pp 956–969. doi: 10.1021/ci400759t
  • Antonia Caroli, Flavio Ballante, Richard B. Wickersham III, Federico Corelli and Rino Ragno. Hsp90 Inhibitors (II). Combining ligand-based and structure-based approaches for Virtual Screening application. J. Chem. Inf. Model., (2014). 54 (3), pp 970–977. doi: 10.1021/ci400760a
Aree interesse: 
  • Chimica Farmaceutica
  • Drug Design
  • Bioinformatica