Total Synthesis of Complex Polycyclic Natural Products beyond Biogenetic Relationships

Abstract: 

Natural products as a source have proven to lead most consistently to successful development of new drugs. Nature assembles whole families of natural products via a single biosynthetic sequence. These molecular architectures are then called biogenetically related, and can be synthesized by mimicking Nature's synthetic sequence. However, this confines biomimetic synthesis to specific structure-types, thus limiting structural diversification. Expanding the synthetic network of natural products beyond biogenetic relationships overcomes these limitations, and will exemplarily be showcased in this talk.